Assess the Knowledge of Medical Students About HTLV-1 in Mashhad University of Medical Science

Houshang Rafat Panah Bayegi, Lida Jarahi, Milad Mahmoudabadi, Masoumeh Sarbaz, Seyyedeh Fatemeh Mousavi Baigi, Khalil Kimiafar



Introduction: Human T-cell lymphotropic virus type 1 (HTLV-1) is known to be endemic in the population of northeastern Iran. This study was conducted with the aim of investigating the knowledge and attitude of medical students of Mashhad University of Medical Sciences about the HTLV-1 virus.

Material and Methods: The present study was a descriptive-analytical study that was conducted in Mashhad Medical School from April to June 2014. The research population included all medical students studying at the time of the study (307 people). The tool of data collection was a questionnaire including 4 parts of demographic characteristics, the amount of information resources used, the level of awareness about HTLV-1 infection and measuring the attitude of students towards HTLV-1 infection. The data was analyzed in the form of descriptive statistics using SPSS 16.0 software.

Results: A total of 271 people responded to the questionnaire (response rate: 88/27). Among the participants, 130 were male and 141 were female. The majority of students, 161 people got their information from the classroom and 157 people were natives of Mashhad. The information obtained from the description of the questions and the percentage of correct answers to the questions showed that the level of students' knowledge about this infection was average with an average score of 16.66 out of 40 points, and the average score of the students' attitude was reported as 68.11 with an average level.

Conclusion: The obtained results reported the level of knowledge of the target group as medium-low, and the level of attitude of this group as medium-high. Also, there was a direct relationship between the amount of information and the level of attitude with the year of entering the university and studying in the university, which reports the slope of this change as low.


Hedayati-Moghaddam MR. Seroepidemiology of human T-cell lymphotropic virus type 1 infection in Iran: An overview. Journal of Medical Council of Islamic Republic of Iran. 2013; 30( 4): 367-78.

Thyagarajan D, Bastian I, Stark RJ, Day BJ, Dax EM, Gilligan BS. HTLV‐I associated myelopathy in a Seychellois immigrant. Med J Aust. 1993; 159(1): 29-31. PMID: 8316110 DOI: 10.5694/j.1326-5377.1993.tb137701.x

Hedayati-Moghaddam MR, Jafarzadeh Esfehani R, El Hajj H, Bazarbachi A. Updates on the epidemiology of the human T-cell leukemia virus type 1 infection in the countries of the eastern mediterranean regional office of the world health organization with special emphasis on the situation in Iran. Viruses. 2022; 14(4): 664. PMID: 35458394 DOI: 10.3390/v14040664

Eusebio-Ponce E, Anguita E, Paulino-Ramirez R, Candel FJ. HTLV-1 infection: An emerging risk. Pathogenesis, epidemiology, diagnosis and associated diseases. Rev Esp Quimioter. 2019; 32(6): 485-96. PMID: 31648512

Boostani R, Lotfinejad N, Zemorshidi F, Vahidi Z, Rezaee SA, Farid R, et al. Planning and management to control and eliminate HTLV-1 infection in Iran. Iran J Basic Med Sci. 2021; 24(3): 264-6. PMID: 33995937 DOI: 10.22038/ijbms.2021.50803.11562

Kalinichenko S, Komkov D, Mazurov D. HIV-1 and HTLV-1 transmission modes: Mechanisms and importance for virus spread. Viruses. 2022; 14(1): 152. PMID: 35062355 DOI: 10.3390/v14010152

Enose-Akahata Y, Vellucci A, Jacobson S. Role of HTLV-1 Tax and HBZ in the pathogenesis of HAM/TSP. Front Microbiol. 2017; 8: 2563. PMID: 29312243 DOI: 10.3389/fmicb.2017.02563

Williams CKO. Global HTLV-1/2 burden and associated diseases. In: Cancer and AIDS. Springer, Cham; 2019.

Willems L, Hasegawa H, Accolla R, Bangham C, Bazarbachi A, Bertazzoni U, et al. Reducing the global burden of HTLV-1 infection: An agenda for research and action. Antiviral Res. 2017; 137: 41-8. PMID: 27840202 DOI: 10.1016/j.antiviral.2016.10.015

Ghaffari J, Kowsarian M, Mahdavi MR, Shahi KV, Rafatpanah H, Tafreshian AR. Prevalence of HTLV-I infection in patients with Thalassemia major in Mazandaran. Jundishapur Journal of Microbiology. 2013; 6(1); 57-60.

World Health Organization. Human T-lymphotropic virus type 1: Technical report [Internet]. 2021 [cited: 15 Jun 2022]. Available from:

Ngoma AM, Omokoko MD, Mutombo PB, Nollet KE, Ohto H. Seroprevalence of human T‐lymphotropic virus (HTLV) in blood donors in sub‐Saharan Africa: A systematic review and meta‐analysis. Vox Sang. 2019; 114(5): 413-25. PMID: 30972789 DOI: 10.1111/vox.12779

Afonso PV, Cassar O, Gessain A. Molecular epidemiology, genetic variability and evolution of HTLV-1 with special emphasis on African genotypes. Retrovirology. 2019; 16(1): 1-5. PMID: 31842895 DOI: 10.1186/s12977-019-0504-z

Caron M, Besson G, Padilla C, Makuwa M, Nkoghé D, Leroy E, et al. Revisiting human T-cell lymphotropic virus types 1 and 2 infections among rural population in Gabon, central Africa thirty years after the first analysis. PLoS Negl Trop Dis. 2018; 12(10): e0006833. PMID: 30359373 DOI: 10.1371/journal.pntd.0006833

Pouliquen J-F, Hardy L, Lavergne A, Kafiludine E, Kazanji M. High seroprevalence of human T-cell lymphotropic virus type 1 in blood donors in Guyana and molecular and phylogenetic analysis of new strains in the Guyana shelf (Guyana, Suriname, and French Guiana). J Clin Microbiol. 2004; 42(5): 2020-6. PMID: 15131164 DOI: 10.1128/JCM.42.5.2020-2026.2004

Anguita E. Seroprevalence and trends of HTLV-1/2 among blood donors of Santo Domingo, Dominican Republic, 2012-2017. Rev Esp Quimioter. 2021; 34(1): 44-50. PMID: 33305921 DOI: 10.37201/req/117.2020

Ramezani A, Aghakhani A, Banifazl M, Boland-Ghamat Z, Foroughi M, Gachkar L, et al. Frequency of human T-cell lymphotropic virus (HTLV) type 1 and 2 infection in HIV infected patients. Iranian Journal of Pathology. 2012; 7(1): 9-13.

Hedayati-Moghaddam MR. A systematic review for estimation of HTLV-I infection in the blood donors of Iran. Iran J Basic Med Sci. 2013; 16(3): 196-201. PMID: 24470861

Shivaraj B, Chandrashekar M, Ranganath T. A study on awareness about HIV/AIDS among first year medical students of Bangalore Medical College and Research Institute. Journal of Evolution of Medical and Dental Sciences. 2015; 4(58): 10023-7.

Cooper CM, James K, Wilks RJ. HTLV-1 related knowledge, attitude and behaviour patterns among mothers who participated in the Jamaica breastfeeding intervention study (1996–2000). West Indian Med J. 2010; 59(1): 35-40. PMID: 20931911

O’Grady L. Meeting health information needs of people with HIV/AIDS: Sources and means of collaboration. Health Info Libr J. 2008; 25(4): 261-9. PMID: 19076672 DOI: 10.1111/j.1471-1842.2007.00764.x

Hogan TP, Palmer CL. Information preferences and practices among people living with HIV/AIDS: results from a nationwide survey. J Med Libr Assoc. 2005; 93(4): 431-9. PMID: 16239938

Dadgar Moghaddam M, Khajedaluee M, Khadem-Rezaiyan M. A Population-based Study into Knowledge, Attitudes and Beliefs (KAB) about HIV/AIDS. Razavi International Journal of Medicine. 2016; 4(1): e34349.

Khani H, Bidarmaghzi M, Halajian E, Azad ME, Majdi M, Khezri M. Knowledge, attitudes, belief and practices in high school students related to AIDS in Mazandaran province, Iran. Journal of North Khorasan University of Medical Sciences. 2011; 3(3): 21-32.

Baytner-Zamir R, Lorber M, Hermoni D. Assessment of the knowledge and attitudes regarding HIV/AIDS among pre-clinical medical students in Israel. BMC Res Notes. 2014; 7: 168. PMID: 24650351 DOI: 10.1186/1756-0500-7-168

Joshi AV, Nikam K, Hungund BR, Viveki RG, Nikam SV, Halappannavar A, et al. Knowledge about and attitude towards HIV/AIDS among first year medical students: A cross-sectional study. Journal of the Scientific Society. 2013; 40(3): 155.

Shamsipour M, Khajehkazemi R, Haghdoost AA, Setayesh H, Kariman Majd S, Mostafavi E. Knowledge, attitude, and practice of clerical students with respect to HIV/AIDS in Iran, 2011. J Relig Health. 2016; 55(1): 26-37. PMID: 25344879 DOI: 10.1007/s10943-014-9964-6

Al-Rabeei N, Dallak A, Al-Awadi F. Knowledge, attitude and beliefs towards HIV/AIDS among students of health institutes in Sana'a city. East Mediterr Health J. 2012; 18(3): 221-6. PMID: 22574474 DOI: 10.26719/2012.18.3.221

Myint KY, Naing KS, Hanni M. Knowledge, awareness and attitudes related to HIV/AIDS among undergraduate medical students of Universiti Malaysia Sabah. International Conference on Education and New Learning Technologies. Barcelona, Spain; 2012.

Hamid Albujeer AN, Shamshiri AR, Taher A. HIV/AIDS awareness among Iraqi medical and dental students. J Int Soc Prev Community Dent. 2015; 5(5): 372-6. PMID: 26539388 DOI: 10.4103/2231-0762.164788

Javed M, Chaudhry R. Knowledge about attitude towards HIV/Aids among first year medical students: A cross-sectional study. Pakistan Journal of Medical and Health Sciences. 2013; 8(2): 295-8.

Haroun D, El Saleh O, Wood L, Mechli R, Al Marzouqi N, Anouti S. Assessing knowledge of, and attitudes to, HIV/AIDS among university students in the United Arab Emirates. PloS One. 2016; 11(2): e0149920. PMID: 26913902 DOI: 10.1371/journal.pone.0149920

Singh VP, Osman IS, Rahmat NA, Bakar NAA, Razak NFNA, Nettem S. Knowledge and attitude of dental students towards HIV/AIDS patients in Melaka, Malaysia. Malays J Med Sci. 2017; 24(3): 73-82. PMID: 28814935 DOI: 10.21315/mjms2017.24.3.9

Kumar S, Tadakamadla J, Areeshi AYBH, Tobaigy HAWM. Knowledge and attitudes towards HIV/AIDS among dental students of Jazan University, Kingdom Saudi Arabia. Saudi Dent J. 2018; 30(1): 47-52. PMID: 30166871 DOI: 10.1016/j.sdentj.2017.10.003

Li R, Dong W, He W, Liu Y. Chinese dental students' knowledge and attitudes toward HIV/AIDS. J Dent Sci. 2016; 11(1): 72-8. PMID: 30894949 DOI: 10.1016/j.jds.2015.09.001

Fowler F, Einsiedel L. A qualitative study exploring perceptions to the human T cell leukaemia virus type 1 in central Australia: Barriers to preventing transmission in a remote aboriginal population. Front Med (Lausanne). 2022; 9: 845594. PMID: 35572972 DOI: 10.3389/fmed.2022.845594

Mousavi Baigi SF, Sarbaz M, Marouzi P, Kimiafar K. Evaluating the impact of digital game on learning medical terminology of paramedical students: Protocol for a randomized controlled trial. Stud Health Technol Inform. 2022; 295: 51-4. PMID: 35773804 DOI: 10.3233/SHTI220658

Mousavi Baigi SF, Moradi F, Vasseifard F, Mohammad Abadi F, Mazaheri Habibi MR. The effect of nutrition training on knowledge of students at university of medical sciences. Topics in Clinical Nutrition. 2022; 37(3): 236-41.



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